{"id":116826,"date":"2025-11-25T15:37:44","date_gmt":"2025-11-25T15:37:44","guid":{"rendered":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/?p=116826"},"modified":"2025-11-25T15:38:39","modified_gmt":"2025-11-25T15:38:39","slug":"why-are-mitochondria-the-key-to-the-new-aesthetic-luxury","status":"publish","type":"post","link":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/?p=116826&lang=en","title":{"rendered":"Why are mitochondria the key to the new aesthetic luxury?"},"content":{"rendered":"<p><strong>In modern aesthetic medicine, true innovation is no longer measured solely by the ability to fill or tighten the skin, but by its potential to reactivate the biological mechanisms of cellular regeneration. At the core of this process are the mitochondria\u2014the \u201cpowerhouses\u201d of our cells\u2014whose function is essential to maintaining skin vitality and health.\u00a0<\/strong><\/p>\n<h3>The\u00a0role\u00a0of\u00a0mitochondria\u00a0in\u00a0the\u00a0skin<\/h3>\n<p><span data-contrast=\"auto\">Through cellular respiration, mitochondria convert oxygen and glucose into <strong>Adenosine Triphosphate (ATP)<\/strong>, the energy currency that enables cells to repair, regenerate, and maintain balance.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">But their role goes far beyond energy production, as they\u00a0perform\u00a0crucial\u00a0<strong>signaling\u00a0functions<\/strong>\u00a0within\u00a0the\u00a0body:<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<ul>\n<li><span data-contrast=\"auto\">Regulate<strong> cellular calcium<\/strong> levels.<\/span><\/li>\n<li><span data-contrast=\"auto\">Control <strong>apoptosis<\/strong> (programmed cell death).<\/span><\/li>\n<li><span data-contrast=\"auto\">Act as <strong>primary regulators<\/strong> of oxygen homeostasis.<\/span><\/li>\n<li><span data-contrast=\"auto\">Are involved in processes such as growth, aging, and adaptive responses.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<h3>The\u00a0root of\u00a0aging:\u00a0mitochondrial\u00a0slowdown and \u201cInflammaging\u201d<\/h3>\n<p><span data-contrast=\"auto\">When this energy machinery begins to fail, cellular metabolism slows, triggering a state of <strong>low-grade chronic inflammation<\/strong> known as <em>inflammaging<\/em>. This process is characterized by <strong>persistent microinflammation<\/strong> that accelerates dermal tissue degradation and promotes the appearance of <strong>wrinkles, spots, and sagging.<\/strong><\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\"><strong>Mitochondrial\u00a0dysfunction,<\/strong>\u00a0especially\u00a0when\u00a0caused\u00a0by\u00a0a\u00a0<strong>lack\u00a0of\u00a0oxygen\u00a0<\/strong>(hypoxia or ischemia), disrupts <strong>cellular homeostasis<\/strong> and unleashes a cascade of <strong>metabolic anomalies<\/strong>. This imbalance increases the risk of<strong> chronic diseases,<\/strong> encourages <strong>neurodegeneration and insulin resistance<\/strong>, and can ultimately lead to <strong>necrosis or cell death.<\/strong><\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">At\u00a0this\u00a0point, a\u00a0<strong>key\u00a0metabolite<\/strong>\u00a0emerges\u2014one\u00a0that\u00a0bridges\u00a0metabolism,\u00a0signaling, and\u00a0cellular\u00a0response:<strong>\u00a0succinic\u00a0acid.<\/strong><\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<h3>Succinic\u00a0acid:\u00a0a\u00a0metabolic\u00a0modulator and\u00a0driver of\u00a0cellular\u00a0bioenergy<\/h3>\n<p><span data-contrast=\"auto\"><strong>Succinic\u00a0acid\u00a0<\/strong>is\u00a0a\u00a0<strong>critical intermediate in the Krebs cycle (or tricarboxylic acid cycle, TCA), <\/strong>a\u00a0process\u00a0that\u00a0occurs\u00a0in\u00a0the\u00a0<strong>mitochondrial\u00a0matrix<\/strong>\u00a0and\u00a0lies\u00a0at\u00a0the\u00a0heart\u00a0of\u00a0cellular\u00a0respiration.\u00a0Beyond\u00a0its\u00a0role in\u00a0energy\u00a0production,\u00a0this\u00a0metabolite\u00a0acts\u00a0as a\u00a0<strong>metabolic\u00a0modulator\u00a0<\/strong>capable\u00a0of\u00a0<strong>reactivating\u00a0mitochondrial\u00a0function<\/strong>,\u00a0stimulating\u00a0<strong>autophagy\u00a0and\u00a0mitophagy<\/strong>, and\u00a0enhancing\u00a0<strong>communication\u00a0between\u00a0fibroblasts\u00a0and\u00a0adipocytes<\/strong>.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">These\u00a0actions\u00a0promote\u00a0the\u00a0synthesis\u00a0of<strong>\u00a0type\u00a0III\u00a0collagen<\/strong>\u00a0and\u00a0<strong>growth\u00a0factors<\/strong>,\u00a0helping\u00a0cells\u00a0<strong>recover\u00a0their\u00a0youthful\u00a0behavior\u00a0<\/strong>and\u00a0maintain\u00a0their\u00a0<strong>energetic\u00a0and regenerative\u00a0capabilities.<\/strong><\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<h3>Inbiotec\u00a0Amber:\u00a0regenerative\u00a0science\u00a0applied to\u00a0cellular\u00a0energy<\/h3>\n<p><span data-contrast=\"auto\">From\u00a0this\u00a0perspective\u00a0emerges\u00a0<strong>Inbiotec\u00a0Amber<\/strong>, IT\u00a0Pharma\u2019s\u00a0first\u00a0\u201cskin\u00a0builder.\u201d\u00a0The\u00a0key\u00a0to\u00a0rejuvenation\u00a0lies\u00a0in \u00ab<strong>rehabilitating<\/strong>\u00bb\u00a0the\u00a0dermal\u00a0ecosystem.\u00a0Its\u00a0formula combines\u00a0two<strong>\u00a0100% biocompatible<\/strong> and\u00a0naturally\u00a0occurring\u00a0actives in\u00a0the\u00a0body:\u00a0hyaluronic\u00a0acid\u00a0(HA) and\u00a0succinic\u00a0acid.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<ul>\n<li><span data-contrast=\"auto\"><strong>Hyaluronic acid<\/strong>, high molecular weight non-crosslinked\u00a0 (\u2248 2 MDa, 1.1%) with hydrating, soothing, and antioxidant effects.<\/span><\/li>\n<li><span data-contrast=\"auto\"><strong>Succinic acid<\/strong> (1.6%), a key metabolite of the Krebs cycle, responsible for activating mitochondrial function and stimulating cellular regeneration. The true star of this product.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-116823 size-full aligncenter\" src=\"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/wp-content\/uploads\/2025\/11\/Diseno-sin-titulo-34.png\" alt=\"dise\u00f1o sin t\u00edtulo (34)\" width=\"800\" height=\"533\" srcset=\"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/wp-content\/uploads\/2025\/11\/Diseno-sin-titulo-34.png 800w, https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/wp-content\/uploads\/2025\/11\/Diseno-sin-titulo-34-300x200.png 300w, https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/wp-content\/uploads\/2025\/11\/Diseno-sin-titulo-34-768x512.png 768w, https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/wp-content\/uploads\/2025\/11\/Diseno-sin-titulo-34-600x400.png 600w, https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/wp-content\/uploads\/2025\/11\/Diseno-sin-titulo-34-64x43.png 64w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/p>\n<p>&nbsp;<\/p>\n<h3>Evidence\u00a0and\u00a0results<\/h3>\n<p><span data-contrast=\"auto\">In vitro\u00a0studies\u00a0have\u00a0demonstrated\u00a0that\u00a0the\u00a0HA +\u00a0succinic\u00a0acid\u00a0combination\u00a0acts\u00a0<strong>synergistically<\/strong>:<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<ul>\n<li><b><span data-contrast=\"auto\">Mitochondrial reactivation:<\/span><\/b><span data-contrast=\"auto\">\u00a0Stimulates\u00a0mitochondrial\u00a0function\u00a0by\u00a0<strong>boosting\u00a0the\u00a0Krebs\u00a0cycle<\/strong>.\u00a0The\u00a0Krebs\u00a0cycle\u00a0is\u00a0fundamental\u00a0to\u00a0cellular\u00a0respiration,\u00a0converting\u00a0pyruvate\u00a0into\u00a0ATP and\u00a0other\u00a0energy\u00a0molecules.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<li><b><span data-contrast=\"auto\">Fibroblast regeneration:<\/span><\/b><span data-contrast=\"auto\">\u00a0This\u00a0metabolic\u00a0stimulation\u00a0aims\u00a0to\u00a0<strong>reverse\u00a0the\u00a0metabolic\u00a0slowdown<\/strong>\u00a0and\u00a0<strong>increase\u00a0the\u00a0number\u00a0and\u00a0activity\u00a0of\u00a0fibroblasts<\/strong>\u2014cells\u00a0critical\u00a0for\u00a0collagen\u00a0and\u00a0elastin\u00a0production.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<li><b><span data-contrast=\"auto\">Combats <em>Inflammaging<\/em>:<\/span><\/b><span data-contrast=\"auto\">\u00a0Succinic\u00a0acid\u00a0provides\u00a0a\u00a0<strong>powerful anti-inflammatory and antioxidant\u00a0 effect<\/strong>.\u00a0It\u00a0helps<strong>\u00a0reduce\u00a0the\u00a0release\u00a0of\u00a0inflammatory\u00a0cytokines\u00a0<\/strong>in\u00a0damaged\u00a0skin and\u00a0neutralizes\u00a0free\u00a0radicals.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<li><b><span data-contrast=\"auto\">Depigmenting effect:<\/span><\/b><span data-contrast=\"auto\"> Succinic acid has a remarkable ability to <strong>reduce hyperpigmentation<\/strong> by chelating copper ions in the tyrosinase enzyme of melanocytes, thus blocking melanin production.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"auto\">Together,\u00a0this\u00a0synergy<strong>\u00a0\u00abreprograms\u00bb\u00a0aged\u00a0cells<\/strong>,\u00a0inducing\u00a0renewal\u00a0processes\u00a0and\u00a0encouraging\u00a0cells\u00a0to\u00a0behave\u00a0more\u00a0youthfully\u2014addressing\u00a0aging\u00a0at\u00a0its\u00a0root.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<h3>Bibliographic references<\/h3>\n<p><span data-contrast=\"auto\">Grimolizzi, F., &amp; Arranz, L. (2018).\u00a0<\/span><i><span data-contrast=\"auto\">Multiple\u00a0faces\u00a0of\u00a0succinate\u00a0beyond\u00a0metabolism\u00a0in\u00a0blood.<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><i><span data-contrast=\"auto\">Haematologica, 103<\/span><\/i><span data-contrast=\"auto\">(10), 1586\u20131592.\u00a0<\/span><a href=\"https:\/\/doi.org\/10.3324\/haematol.2018.196097\"><span data-contrast=\"none\">https:\/\/doi.org\/10.3324\/haematol.2018.196097<\/span><\/a><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Huang, H., Li, G., He, Y., Chen, J., Yan, J., Zhang, Q., Li, L., &amp;\u00a0Cai, X. (2024).\u00a0<\/span><i><span data-contrast=\"auto\">Cellular\u00a0succinate\u00a0metabolism\u00a0and\u00a0signaling\u00a0in\u00a0inflammation:\u00a0Implications\u00a0for\u00a0therapeutic\u00a0intervention.<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><i><span data-contrast=\"auto\">Frontiers\u00a0in\u00a0Immunology, 15<\/span><\/i><span data-contrast=\"auto\">, 1404441.\u00a0<\/span><a href=\"https:\/\/doi.org\/10.3389\/fimmu.2024.1404441\"><span data-contrast=\"none\">https:\/\/doi.org\/10.3389\/fimmu.2024.1404441<\/span><\/a><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Lukyanova, L. D., &amp;\u00a0Kirova, Y. I. (2015).\u00a0<\/span><i><span data-contrast=\"auto\">Mitochondria-controlled\u00a0signaling\u00a0mechanisms\u00a0of\u00a0brain\u00a0protection\u00a0in\u00a0hypoxia.<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><i><span data-contrast=\"auto\">Frontiers\u00a0in\u00a0Neuroscience, 9<\/span><\/i><span data-contrast=\"auto\">, 320.\u00a0<\/span><a href=\"https:\/\/doi.org\/10.3389\/fnins.2015.00320\"><span data-contrast=\"none\">https:\/\/doi.org\/10.3389\/fnins.2015.00320<\/span><\/a><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Tannahill, G. M., Curtis, A. M.,\u00a0Adamik, J.,\u00a0Palsson-McDermott, E. M.,\u00a0McGettrick, A. F.,\u00a0Goel, G., et al. (2013).\u00a0<\/span><i><span data-contrast=\"auto\">Succinate\u00a0is\u00a0an\u00a0inflammatory\u00a0signal\u00a0that\u00a0induces IL-1\u03b2\u00a0through\u00a0HIF-1\u03b1.<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><i><span data-contrast=\"auto\">Nature, 496<\/span><\/i><span data-contrast=\"auto\">(7444), 238\u2013242.\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1038\/nature11986\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1038\/nature11986<\/span><\/a><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Tretter, L.,\u00a0Patocs, A., &amp;\u00a0Chinopoulos, C. (2016).\u00a0<\/span><i><span data-contrast=\"auto\">Succinate,\u00a0an\u00a0intermediate\u00a0in\u00a0metabolism,\u00a0signal\u00a0transduction, ROS,\u00a0hypoxia, and\u00a0tumorigenesis.<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><i><span data-contrast=\"auto\">Biochimica\u00a0et\u00a0Biophysica\u00a0Acta (BBA) &#8211;\u00a0Bioenergetics, 1857<\/span><\/i><span data-contrast=\"auto\">(8), 1086\u20131101.\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1016\/j.bbabio.2016.03.012\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.bbabio.2016.03.012<\/span><\/a><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Trauelsen, M.,\u00a0Hiron, T. K., Lin, D., Petersen, J. E., Breton, B.,\u00a0Husted, A. S., et al. (2021).\u00a0<\/span><i><span data-contrast=\"auto\">Extracellular\u00a0succinate\u00a0hyperpolarizes\u00a0M2\u00a0macrophages\u00a0through\u00a0SUCNR1\/GPR91-mediated\u00a0Gq\u00a0signaling.<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><i><span data-contrast=\"auto\">Cell\u00a0Reports, 35<\/span><\/i><span data-contrast=\"auto\">(10), 109246.\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1016\/j.celrep.2021.109246\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.celrep.2021.109246<\/span><\/a><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Turkevych, A., Derkach, N.,\u00a0Kupriyanova, A.,\u00a0Zubair, L.,\u00a0Turkevych, M., &amp;\u00a0Turkevych, D. (2020).\u00a0<\/span><i><span data-contrast=\"auto\">Improving\u00a0skin\u00a0quality\u00a0with\u00a0hyaluronic\u00a0and\u00a0succinic\u00a0acid.<\/span><\/i><span data-contrast=\"auto\">\u00a0Art\u00edculo de revista\/congreso publicado en\u00a0ResearchGate, enero 2020.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">de Castro Fonseca, M., Aguiar, C. J., da Rocha Franco, J. A.,\u00a0Gingold, R. N., &amp;\u00a0Leite, M. F. (2016).\u00a0<\/span><i><span data-contrast=\"auto\">GPR91:\u00a0Expanding\u00a0the\u00a0frontiers\u00a0of\u00a0Krebs\u00a0cycle\u00a0intermediates.<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><i><span data-contrast=\"auto\">Cell\u00a0Communication\u00a0and\u00a0Signaling, 14<\/span><\/i><span data-contrast=\"auto\">, 3.\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1186\/s12964-016-0126-1\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1186\/s12964-016-0126-1<\/span><\/a><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Papurina, T.,\u00a0Barsukov, O.,\u00a0Zabuga, O.,\u00a0Krasnienkov, D., &amp; Denis, E. (2023).\u00a0<\/span><i><span data-contrast=\"auto\">Effects\u00a0of\u00a0succinic\u00a0acid\u00a0on\u00a0dermal\u00a0fibroblasts\u00a0during\u00a0cultivation\u00a0under\u00a0extremely\u00a0hypoxic\u00a0conditions.<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><i><span data-contrast=\"auto\">Biochemistry\u00a0and\u00a0Biophysics\u00a0Reports, 33<\/span><\/i><span data-contrast=\"auto\">, 101429.\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1016\/j.bbrep.2023.101429\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.bbrep.2023.101429<\/span><\/a><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Mia, R. (2017).\u00a0<\/span><i><span data-contrast=\"auto\">Combining\u00a0HA\u00a0with\u00a0Sodium\u00a0Succinate.<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><i><span data-contrast=\"auto\">Aesthetics\u00a0Journal, 7<\/span><\/i><span data-contrast=\"auto\">(4).<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Ceccarelli, M. (s.f.).\u00a0<\/span><i><span data-contrast=\"auto\">Treating\u00a0hyperpigmentation\u00a0using\u00a0a\u00a0combination\u00a0of\u00a0hyaluronic\u00a0and\u00a0succinic\u00a0acids.<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><i><span data-contrast=\"auto\">PRIME\u00a0Journal.<\/span><\/i><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Tsepkolenko, V., &amp;\u00a0Medvedeva, I. (2010).\u00a0<\/span><i><span data-contrast=\"auto\">Redermalization:\u00a0Results\u00a0and\u00a0prospects.<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><i><span data-contrast=\"auto\">Les\u00a0nouvelles\u00a0esth\u00e9tiques, 5<\/span><\/i><span data-contrast=\"auto\">(63).<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In modern aesthetic medicine, true innovation is no longer measured solely by the ability to fill or tighten the skin, but by its potential to reactivate the biological mechanisms of cellular regeneration. At the core of this process are the mitochondria\u2014the \u201cpowerhouses\u201d of our cells\u2014whose function is essential to maintaining skin vitality and health.\u00a0 The\u00a0role\u00a0of\u00a0mitochondria\u00a0in\u00a0the\u00a0skin [&hellip;]<\/p>\n","protected":false},"author":94,"featured_media":116825,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"none","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"categories":[877],"tags":[],"class_list":{"0":"post-116826","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-sin-categoria-en"},"_links":{"self":[{"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=\/wp\/v2\/posts\/116826","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=\/wp\/v2\/users\/94"}],"replies":[{"embeddable":true,"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=116826"}],"version-history":[{"count":2,"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=\/wp\/v2\/posts\/116826\/revisions"}],"predecessor-version":[{"id":116833,"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=\/wp\/v2\/posts\/116826\/revisions\/116833"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=\/wp\/v2\/media\/116825"}],"wp:attachment":[{"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=116826"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=116826"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=116826"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}