{"id":111351,"date":"2025-11-03T15:32:24","date_gmt":"2025-11-03T15:32:24","guid":{"rendered":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/?p=111351"},"modified":"2025-11-14T12:09:49","modified_gmt":"2025-11-14T12:09:49","slug":"skinscience-by-it-pharma-inbiotec-amber-physiology-how-it-rehabilitates-skin-cells-for-deep-regeneration","status":"publish","type":"post","link":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/?p=111351&lang=en","title":{"rendered":"SkinScience By IT Pharma – Inbiotec Amber Physiology: how it rehabilitates skin cells for deep regeneration"},"content":{"rendered":"

At the forefront of aesthetic medicine, the approach has evolved from superficial correction to regenerative treatment. The new luxury in aesthetics is healthy, functional, and long-lasting skin. Inbiotec Amber aligns with this philosophy as the first \u00abskin builder,\u00bb a medical injectable that rehabilitates the skin from its physiology, targeting both chrono- and photoaging. It is a medical device that contains 1.1% (11 mg\/ml) high molecular weight hyaluronic acid (HA) (approximately 2 MDa) and 1.6% (16.9 mg\/ml) succinic acid (SA).\u00a0<\/strong><\/p>\n

The concept of cellular \u201crehabilitation\u201d is based on the synergy of its two main components, both biocompatible and naturally present in the body. Let\u2019s take a closer look.<\/span>\u00a0<\/span><\/p>\n

Skinbuilding Action: the power of Hyaluronic Acid and Succinic Acid<\/h3>\n

The skin builder concept of Inbiotec Amber lies in the combination of two biocompatible actives we\u2019ve already introduced. This synergy addresses the three primary causes of skin aging:<\/span>\u00a0<\/span><\/p>\n

    \n
  1. Dehydration and volume loss:<\/span><\/b> Skin aging is characterized by the reduction of HA in the skin, which leads to loss of volume, hydration, elasticity, and firmness. The HA in Amber is high molecular weight (HMW-HA) and non-crosslinked, which means it does not act as a volumizing filler, but as a deep hydrator and structural support in the dermis that attracts water.<\/span>\u00a0<\/span><\/li>\n<\/ol>\n
      \n
    1. Metabolic slowdown:<\/span><\/b> Aging involves a deceleration of cellular metabolic processes, resulting in a slower production of collagen and elastin, which are responsible for the skin\u2019s structure.<\/span>\u00a0<\/span><\/li>\n<\/ol>\n
        \n
      1. Oxidative stress (accumulation of free radicals):<\/span><\/b> The build-up of free radicals (pollution, UV radiation, smoking, etc.) and the phenomenon of low-grade chronic inflammation, known as \u00abinflammaging\u00bb, are key drivers of premature aging and deterioration of skin quality.<\/span>\u00a0<\/span><\/li>\n<\/ol>\n

        Energy recovery: Succinic Acid as a mitochondrial stimulant<\/h3>\n

        As mentioned, chronological aging is marked by a slowdown in cellular metabolic processes<\/strong>. Succinic acid, as an essential metabolite, directly addresses this cause.<\/span>\u00a0<\/span><\/p>\n

        Succinate is a fundamental intermediate in the Krebs Cycle<\/strong> (or tricarboxylic acid cycle, TCA), which takes place in the mitochondria and is crucial for cellular respiration and energy production.<\/span>\u00a0<\/span><\/p>\n

        The stimulation of succinic acid<\/strong> helps reverse this metabolic slowdown<\/strong> and boost cellular metabolic processes<\/strong>. This mitochondrial activation leads to increased production of Adenosine Triphosphate (ATP)<\/strong> and NADH<\/strong>. This greater energy (ATP)<\/strong> translates into enhanced cellular repair<\/strong> and improved cell function, increasing skin elasticity, firmness, and smoothness.<\/span>\u00a0<\/span><\/p>\n

        Dermal and structural regeneration<\/h3>\n

        The metabolic reactivation induced by succinate has a direct and powerful effect on fibroblasts, the cells responsible for synthesizing the structural components of the dermis. In vitro studies show that HA and sodium succinate act synergistically<\/strong> to stimulate these cells with a greater effect than HA alone. The number of fibroblasts can increase by up to 300%<\/strong> with the combination, compared to 200% with HA as a single component.<\/span>\u00a0<\/span><\/p>\n

        This increase in fibroblast activity leads to accelerated synthesis of collagen and elastin<\/strong>. Furthermore, treatment with sodium succinate (alone or combined with HA) showed a significant increase in the expression of key growth factors<\/strong> for tissue repair.<\/span>\u00a0<\/span><\/p>\n

        Controlling Inflammaging\u00a0<\/em><\/h3>\n

        Aging is associated with inflammaging<\/em>, a low-grade chronic inflammation that accelerates tissue degradation. Succinate provides a strong anti-inflammatory effect<\/strong> that helps reduce the release of inflammatory cytokines.<\/strong><\/span>\u00a0<\/strong><\/p>\n

        Recent research indicates that the succinate\/SUCNR1 system is involved in the formation of the reparative (anti-inflammatory M2) macrophage phenotype<\/strong>. Activation of SUCNR1 in immune system cells (such as macrophages) can modulate the transcription of immune function genes<\/strong>, promoting an anti-inflammatory program and facilitating tissue repair<\/strong>.<\/span>\u00a0<\/span><\/p>\n

        When shifting to the \u00abrepair mode (M2),\u00bb<\/strong> these macrophages release growth factors (such as VEGF<\/strong> for angiogenesis and TGF\u03b21<\/strong> for fibroblast proliferation) and help block inflammaging<\/em><\/strong>.<\/span>\u00a0<\/span><\/p>\n

        Clearly visible clinical results<\/h3>\n

        Thanks to its innovative combination of hyaluronic acid and succinic acid, Inbiotec Amber offers genuine cellular skin rehabilitation, acting simultaneously on four key factors of aging: dehydration, metabolic slowdown, oxidative stress, and chronic inflammation.<\/span>\u00a0<\/span><\/p>\n

        The visible clinical result is more hydrated, elastic, and firm skin<\/strong>, with an improvement that goes beyond the surface. This \u201cskin builder\u201d approach positions Inbiotec Amber as a comprehensive solution for skin rejuvenation and dermal healing.<\/span>\u00a0<\/span><\/p>\n

        Bibliographic References<\/h3>\n

        Ceccarelli, M. (s.f.). Treating hyperpigmentation using a combination of hyaluronic and succinic acids. <\/span>PRIME Journal<\/span><\/i>.<\/span>\u00a0<\/span><\/p>\n

        de Castro Fonseca, M., Aguiar, C. J., da Rocha Franco, J. A., Gingold, R. N., & Leite, M. F. (2016). GPR91: Expanding the frontiers of Krebs cycle intermediates. <\/span>Cell Communication and Signaling, 14<\/span><\/i>(3). doi: 10.1186\/s12964-016-0126-1.<\/span>\u00a0<\/span><\/p>\n

        Denton, C. R., Lerner, A. B., & Fitzpatrick, T. B. (1952). Inhibition of melanin formation by chemical agents. <\/span>The Journal of Investigative Dermatology, 18<\/span><\/i>, 119\u2013135.<\/span>\u00a0<\/span><\/p>\n

        Grimolizzi, F., & Arranz, L. (2018). Multiple faces of succinate beyond metabolism in blood. <\/span>Haematologica, 103<\/span><\/i>(10), 1586\u20131592.<\/span>\u00a0<\/span><\/p>\n

        Huang, H., Li, G., He, Y., Chen, J., Yan, J., Zhang, Q., Li, L., & Cai, X. (2024). Cellular succinate metabolism and signaling in inflammation: implications for therapeutic intervention. <\/span>Frontiers in Immunology, 15<\/span><\/i>:1404441. doi: 10.3389\/fimmu.2024.1404441.<\/span>\u00a0<\/span><\/p>\n

        Mia, R. (2016). Combining HA with sodium succinate. <\/span>Aesthetics Journal<\/span><\/i>.<\/span>\u00a0<\/span><\/p>\n

        Sister, D. (2017). Combination injectable treatments to rejuvenate the ageing face. <\/span>International Journal of Aesthetic and Anti-Ageing Medicine, 7<\/span><\/i>(4).<\/span>\u00a0<\/span><\/p>\n

        Trauelsen, M., Hiron, T. K., Lin, D., Petersen, J. E., Breton, B., Husted, A. S., et al. (2021). Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1\/GPR91-mediated Gq signaling. <\/span>Cell Reports, 35<\/span><\/i>(10), 109246. doi: 10.1016\/j.celrep.2021.109246.<\/span>\u00a0<\/span><\/p>\n

        Tretter, L., Tretter, T., Liska, M., Chinopoulos, C., Murphy, M. P., & Krieg, T. (2016). Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis. <\/span>Biochimica et Biophysica Acta (BBA), 1857<\/span><\/i>(8), 1086\u20131101. doi:10.1016\/j.bbabio.2016.03.012.<\/span>\u00a0<\/span><\/p>\n

        Turkevych, A., Derkach, N., Kupriyanova, A., Zubair, L., Turkevych, M., & Turkevych, D. (2020). Improving skin quality with hyaluronic and succinic acid. <\/span>Art\u00edculo\/Publicaci\u00f3n<\/span><\/i>.<\/span>\u00a0<\/span><\/p>\n

        Yasuda, M., Yamasaki, K., & Ohtaki, H. (1960). Stability of complexes of several carboxylic acids formed with bivalent metals. <\/span>Bulletin of the Chemical Society of Japan, 33<\/span><\/i>(8), 1067\u20131070.<\/span>\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

        At the forefront of aesthetic medicine, the approach has evolved from superficial correction to regenerative treatment. The new luxury in aesthetics is healthy, functional, and long-lasting skin. Inbiotec Amber aligns with this philosophy as the first \u00abskin builder,\u00bb a medical injectable that rehabilitates the skin from its physiology, targeting both chrono- and photoaging. It is […]<\/p>\n","protected":false},"author":94,"featured_media":114262,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"none","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"categories":[877],"tags":[],"class_list":{"0":"post-111351","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-sin-categoria-en"},"_links":{"self":[{"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=\/wp\/v2\/posts\/111351","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=\/wp\/v2\/users\/94"}],"replies":[{"embeddable":true,"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=111351"}],"version-history":[{"count":1,"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=\/wp\/v2\/posts\/111351\/revisions"}],"predecessor-version":[{"id":111359,"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=\/wp\/v2\/posts\/111351\/revisions\/111359"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=\/wp\/v2\/media\/114262"}],"wp:attachment":[{"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=111351"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=111351"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fervent-dubinsky.82-165-171-139.plesk.page\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=111351"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}